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    Recombinant Mouse M-CSF巨噬細(xì)胞集落刺激因子

    • 更新時間:  2023-07-24
    • 產(chǎn)品型號:  R&D 416-ml
    • 簡單描述
    • Recombinant Mouse M-CSF巨噬細(xì)胞集落刺激因子
      上海力敏代理R&D產(chǎn)品,美國*Recombinant Mouse M-CSF,Recombinant human M-CSF,規(guī)格分別是10ug和50ug 咨詢
      還有人的Human M-CSF
    詳細(xì)介紹

    Recombinant Mouse M-CSF巨噬細(xì)胞集落刺激因子

    MCSF,
    also known as CSF1,
    is a fourαhelicalbundle
    cytokine that is the primary regulator of macrophage survival, proliferation and differentiation (1 3).
    MCSF
    is also essential for the survival and proliferation of osteoclast progenitors (1, 4). MCSF
    also primes and enhances macrophage killing of tumor cells and
    microorganisms, regulates the release of cytokines and other inflammatory modulators from macrophages, and stimulates pinocytosis (2, 3). MCSF
    increases during
    pregnancy to support implantation and growth of the decidua and placenta (5). Sources of MCSF
    include fibroblasts, activated macrophages, endometrial secretory
    epithelium, bone marrow stromal cells and activated endothelial cells (1 5).
    The MCSF
    receptor (cfms)
    transduces its pleotropic effects and mediates its
    endocytosis. MCSF
    mRNAs of various sizes occur (3 9).
    Full length mouse MCSF
    transcripts encode a 520 amino acid (aa) type I transmembrane (TM) protein with
    a 462 aa extracellular region, a 21 aa TM domain, and a 37 aa cytoplasmic tail that forms a 140 kDa covalent dimer. Differential processing produces two
    proteolytically cleaved, secreted dimers. One is an Nand
    Oglycosylated
    86 kDa dimer, while the other is modified by both glycosylation and chondroitinsulfate
    proteoglycan (PG) to generate a 200 kDa subunit. Although PGmodified
    MCSF
    can circulate, it may be immobilized by attachment to type V collagen (8). Shorter
    transcripts encode M CSF
    that lacks cleavage and PG sites and produces an Nglycosylated
    68 kDa TM dimer and a slowly produced 44 kDa secreted dimer (7).
    Although forms may vary in activity and halflife,
    all contain the Nterminal
    150 aa portion that is necessary and sufficient for interaction with the M CSF
    receptor
    (10, 11). The first 229 aa of mature mouse MCSF
    shares 87%, 83%, 82% and 81% aa identity with corresponding regions of rat, dog, cow and human MCSF,
    respectively (12, 13). Human MCSF
    is active in the mouse, but mouse MCSF
    is reported to be speciesspecific

    Recombinant Mouse M-CSF巨噬細(xì)胞集落刺激因子

     

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